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Pharmaceutical counterions

Separation of negatively charged counterions

Methods for simultaneous analysis of pharmaceutical counterions using  Xenoic® XAMS suppressor and ASUREX-A200 automatic regenerator enhancing sensitivity and reducing background and noise.

Separation of pharmaceutical counterions on a Metrosep A Supp 10 column (250x4 mm) using an eluent containing 12 mM Na₂CO₃ and 24 mM NaHCO₃ in water pumped at 1.0 mL/min at 24 °C. Background reduced to ~38 µS/cm by XAMS suppressor with ASUREX-A200 automatic regenerator. Eluent pumping and conductivity detection by Metrohm 761 Compact IC. Injection of 20 µL of acetate (1), formate (2), mesylate (3), chloride (4), phosphate (5), succinate (6), malate (7), tartrate (8), maleate (9), sulfate (10), bromide (11), oxalate (12), nitrate (13), besylate (14), fumarate (15), tosylate (16), at 5 or 20 mg/L (inorganic ions and organic acids, respectively) in water, giving signals up to 6 µS/cm. 

Separation of pharmaceutical counterions on a Shodex IC SI-50 4E column (250x4 mm) using an eluent containing 4 mM Na₂CO₃ and 12 mM NaHCO₃ in water pumped at 0.8 mL/min at 24 °C. Background reduced to ~25 µS/cm by XAMS suppressor with ASUREX-A200 automatic regenerator. Eluent pumping and conductivity detection by Metrohm 761 Compact IC. Injection of 20 µL of acetate (1), mesylate (2), chloride (3), bromide (4), phosphate (5), nitrate (6), malate (7), sulfate (8), maleate (9), tartrate (10), oxalate (11), fumarate (12), at 5 or 20 mg/L (inorganic ions and organic acids, respectively) in water, giving signals up to 8 µS/cm.