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Alternative methods for voriconazole

Analysis of chloride and voriconazole impurity E

Ion chromatography conditions for determination of chloride and camphor-10-sulfonic acid using Xenoic® XAMS suppressor with ASUREX-A200 automatic regenerator.

Alternative to European Pharmacopeia monograph method 2576. Ion chromatography separation of Voriconazole related substances impurity E and chloride on a Shodex IC SI-90 4E column (250x4 mm) using an eluent containing 95% aqueous 4 mM NaHCO₃ and 0.5 mM Na₂CO₃ with 5% acetonitrile, pumped at 1.5 mL/min at 25 °C. Background reduced by XAMS suppressor with ASUREX-A200 automatic regenerator. Eluent pumping and conductivity detection by Metrohm 761 Compact IC. Injection of 20 µL of chloride (5 mg/L), and voriconazole impurity E (camphor-10-sulfonic acid, 20 mg/L) in water, giving signals up to about 2.5 µS/cm.